cellcyclecheckpointprotein

2022年7月30日 — What you'll learn to do: Identify and explain the important checkpoints that a cell passes through during the cell cycle.

The key role of checkpoint proteins is to detect DNA damage and send a signal to delay cell cycle advance until the damaged chromosomes are repaired (Figure 1).

Specific cell cycle checkpoints interrupt or slow down the cell cycle in response to DNA damage during interphase, replication stress during the S phase, or ...

Cell cycle checkpoints ... A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and decides whether or not ...

由 M Molinari 著作 · 2000 · 被引用 464 次 — Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on ...

Two groups of proteins, called cyclins and cyclin-dependent kinases (Cdks), are responsible for the progress of the cell through the various checkpoints. The ...

由 KJ Barnum 著作 · 2014 · 被引用 724 次 — Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle.

由 AF Straight 著作 · 1997 · 被引用 63 次 — Recent work has shown that two of the spindle assembly checkpoint proteins, Mad2 and Bub1, localize to the kinetochores of vertebrate cells for part of mitosis.

由 Y Wang 著作 · 2009 · 被引用 192 次 — Cell cycle checkpoints provide mechanisms for cells to repair DNA damage. Activated checkpoints slow down cell cycle progression and thus allow ...